Effect of Fresh Frozen Plasma Infusion on Hospital Length of Stay for Patients With Hereditary Angioedema

Background: Patients with hereditary angioedema treated with fresh frozen plasma (FFP) infusion face complications and risk of side effects. Objective: To study the effect of FFP infusion on hospital length of stay for patients with hereditary angioedema. Methods: Data from the 2021 Nationwide Inpatient Sample were used to identify hospitalized patients with hereditary angioedema. Patient demographics, comorbidities, and severity measures were analyzed, and a Bayesian additive regression tree model was used to assess factors contributing to length of stay. Results: FFP infusion was found to be associated with increased length of stay for patients with risk factors such as respiratory, cardiovascular disease, or urticaria. Conclusions: Caution is recommended when planning to use FFP, to ensure that underlying patient conditions and risk factors are thoroughly understood. The findings emphasize the need for personalized treatment plans based on individual risk factors, with a recommendation for prioritizing C1-inhibitor therapy over FFP.