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Updated: May 2, 2026

Fully Autonomous Characterization and Data Collection from Crystals of Biological Macromolecules
Published on: March 22, 2019
Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL
1Swiss Light Source, Center for Photon Science, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen, Switzerland.
Abstract:
This review highlights the development and evolution of three macromolecular crystallography (MX) beamlines at the Swiss Light Source (SLS) over the past two decades. We discuss key advancements in X-ray optics, detectors, goniometers, sample changers and MX methodology, emphasizing their impact on high-throughput and high-resolution structural biology. Our contributions are presented within the broader context of global efforts in synchrotron-based MX. Looking ahead, we explore the future experiments enabled by SLS 2.0 and new opportunities at SwissFEL to enhance experimental capabilities and drive scientific discoveries.
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