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Updated: Sep 15, 2025

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
Choroidal Neovascularization in Peripapillary Persistent Fetal Vasculature Syndrome: A Possible Sequela of
Justin J Grassmeyer1, J Peter Campbell1, Aristomenis Thanos2
1The Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University and.
Abstract:
Persistent fetal vasculature (PFV) refers to a spectrum of developmental ocular anomalies due to incomplete regression of embryonic vasculature. PFV may present with a wide range of manifestations and visual consequences. We report a rare manifestation of PFV wherein an exudative choroidal neovascular membrane formed in association with the posterior origin of the fibrovascular stalk. While most PFV stalks arise from the optic disc, the stalk in this case originated away from the disc in the inferonasal peripapillary area and had not undergone surgical transection. The patient was treated with intravitreal anti-vascular endothelial growth factor injections with sustained improvement in vision and exudation.

