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Updated: Sep 15, 2025
10:18
Ascending Aortic Constriction in Rats for Creation of Pressure Overload Cardiac Hypertrophy Model
Published on: June 29, 2014
17.3K
SARM1 Exacerbates Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Enhancing NAD+ Metabolism
Hui-Ting Shi1, Guo-Jun Zhao1, Si-Jia Liu2
1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China.
Summary
Sterile alpha and TIR motifs of 1 (SARM1) exacerbates heart failure (HF) by depleting cardiac nicotinamide adenine dinucleotide (NAD+). Suppressing SARM1 or supplementing NAD+ may offer new therapeutic strategies for HF patients.
Area of Science:
- Biochemistry
- Cardiovascular Biology
- Molecular Medicine
Background:
- Heart failure (HF) is a critical condition with high mortality.
- Nicotinamide adenine dinucleotide (NAD+) is vital in HF.
- The role of Sterile alpha and TIR motifs of 1 (SARM1) in HF is unknown.
Purpose of the Study:
- To investigate the role of SARM1 in heart failure.
- To determine if SARM1 impacts cardiac NAD+ levels and function.
Main Methods:
- Created mouse and cell models of HF using transverse aortic constriction and phenylephrine stimulation.
- Assessed the effects of Sarm1 gene deletion and overexpression.
- Measured NAD+ levels, mitochondrial function, and cardiac remodeling.
Main Results:
- SARM1 expression significantly increased in HF models.
- SARM1 suppression improved cardiac function and remodeling.
- SARM1 overexpression worsened HF by reducing NAD+ and impairing mitochondrial bioenergetics.
- Nicotinamide mononucleotide (NMN) supplementation counteracted SARM1-induced hypertrophy.
Conclusions:
- SARM1 is a key contributor to HF progression by lowering cardiac NAD+ levels.
- Targeting SARM1 presents a potential therapeutic avenue for heart failure.
Keywords:
NAD+ metabolismcardiac hypertrophyheart failuremitochondrial dysfunctionsterile alpha and TIR motif containing 1More Related Videos
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