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High-Performance Guided Mode Resonance Optofluidic Sensor.

Liang Guo1, Lei Xu1,2, Liying Liu1

  • 1Key Laboratory for Micro and Nanophotonic Structures (Ministry of Education, China), Department of Optical Science and Engineering, School of Information Science and Engineering, Fudan University, Shanghai 200433, China.

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Summary
This summary is machine-generated.

This study presents a high-performance thick-waveguide guided mode resonance (GMR) sensor. Optimized waveguide thickness enhances sensitivity and figure of merit (FOM) for advanced label-free biosensing applications.

Keywords:
figure of meritguided mode resonanceoblique incidenceoptical refractive index sensoroptofluidic sensorsensitivity

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Area of Science:

  • Photonics and Sensing Technologies
  • Nanophotonics
  • Biomedical Engineering

Background:

  • Guided Mode Resonance (GMR) sensors offer label-free detection capabilities.
  • Optimizing GMR sensor performance is crucial for sensitive and reliable biosensing.
  • Existing GMR sensors face challenges in achieving high sensitivity and figure of merit (FOM) simultaneously.

Purpose of the Study:

  • To investigate the effect of waveguide thickness on GMR sensor performance.
  • To achieve a high sensitivity and high figure of merit (FOM) in a GMR sensor.
  • To demonstrate the potential of the developed GMR sensor for practical label-free biosensing.

Main Methods:

  • Theoretical calculations to determine optimal waveguide thickness for GMR excitation.
  • Experimental fabrication and characterization of a thick-waveguide GMR sensor.
  • Performance evaluation including sensitivity, resonance linewidth, FOM, and detection limit.

Main Results:

  • Achieved a high sensitivity of 1255.78 nm/RIU.
  • Obtained a resonance linewidth of 0.59 nm at 535 nm.
  • Demonstrated a figure of merit (FOM) of 2128 RIU-1 and a detection limit of 1.74 × 10-7 RIU.
  • Utilized a microfluidic hemisphere and polymer materials to reduce liquid consumption and fabrication cost.

Conclusions:

  • The thick-waveguide GMR sensor exhibits unprecedented comprehensive performance.
  • The sensor design shows significant potential for highly sensitive label-free biosensing.
  • The integration of microfluidics and polymer materials enhances practical applicability and cost-effectiveness.