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Updated: Sep 8, 2025

Author Spotlight: Unraveling the Pathogenesis of Age-Related Macular Degeneration and Discovering Potential Therapies
Published on: July 28, 2023
Late-Onset Retinal Degeneration
Stephen H Tsang1, Tarun Sharma2
1Department of Ophthalmology, Columbia University, New York, NY, USA. sht2@cumc.columbia.edu.
Abstract:
Patients with late-onset retinal degeneration (LORD) usually present with nyctalopia in the fifth or sixth decade of life. The fundus shows yellowish-white, punctate deposits, usually progressive and giving rise to scalloped areas of retinal pigment epithelium (RPE) atrophy in the mid-periphery and posterior pole (Fig. 23.1). The anterior segment shows elongated zonules with central lens insertion and transillumination defect in the iris, due to iris atrophy.

