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CYTOTOXICITY ASSESSMENT OF ADHESIVE SYSTEM COMPONENTS CONTAINING METHACRYLOYLOXYDECYL DIHYDROGEN PHOSPHATE.

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Dental adhesive systems containing Methacryloyloxydecyl dihydrogen phosphate (MDP-10) vary in cytotoxicity. A synthesized MDP-10 primer showed the lowest toxicity, suggesting custom formulations may be safer for dental applications.

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Area of Science:

  • Dental Materials Science
  • Biocompatibility Studies
  • Restorative Dentistry

Background:

  • Dental adhesives are crucial in restorative dentistry, necessitating evaluation of their safety and biocompatibility.
  • Methacryloyloxydecyl dihydrogen phosphate (MDP-10) is a common monomer, but its cytotoxicity requires further investigation.

Purpose of the Study:

  • To compare the cytotoxic effects of five MDP-10 containing dental adhesive systems on human gingival mesenchymal stromal cells (hGMSCs).
  • To assess cytotoxicity of a laboratory-synthesized MDP-10 primer compared to commercial adhesives.

Main Methods:

  • Five MDP-10 based adhesive materials were tested on hGMSCs from attached and movable gingiva.
  • Cell viability, apoptosis, and necrosis were analyzed using Annexin V-FITC/PI staining and flow cytometry.
  • Statistical analysis was performed using the Mann-Whitney U test.

Main Results:

  • Three of the tested adhesives exhibited significant cytotoxicity, increasing cell death.
  • The synthesized MDP-10 primer demonstrated the lowest cytotoxicity, maintaining over 60% cell viability.
  • No significant differences in cytotoxicity were found between cells from attached and movable gingiva.

Conclusions:

  • MDP-10 based dental adhesives possess varying cytotoxic potentials, influenced by composition and purity.
  • Custom-synthesized MDP-10 primers may offer improved biocompatibility over commercial formulations.
  • Careful selection of dental materials and further in vivo studies are recommended.