Related Experiment Video
Updated: Sep 12, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
Sickle Cell Disease and Other Causes of Anemia
Raina A Meka1, Julia Whitley1, Amanda C Zofkie1
1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.
Abstract:
Sickle cell disease is a prevalent autosomal recessive hemoglobinopathy with significant maternal and neonatal risks during pregnancy. Pre-pregnancy management involves counseling, baseline health assessment, genetic testing, and medication review. During pregnancy, care focuses on folic acid supplementation, serial growth scans, antenatal testing, and tailored pain management for acute crises and chronic pain. Delivery planning and peri-partum considerations involve timing, mode, and pain control. A multidisciplinary approach is critical for optimizing outcomes.
More Related Videos
Related Concept Videos
Disorders of Erythrocytes
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
Multiple Allele Traits
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

