Palladium-Catalyzed Cascade Transformations of 1,4-Diyn-3-yl Carbonates to Construct Cyclobutane-Embedded Frameworks
Li Li1, Ze-Liang He1, Hao Wang1
1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
Abstract:
A palladium-catalyzed autotandem reaction between 1,4-diyn-3-yl carbonates and ortho-functionalized activated alkenes is presented, proceeding through a sequential allenylation, vinylogous addition, and intramolecular propargylation process. A broad array of fused and spirocyclic architectures that include a cyclobutane motif are straightforwardly constructed in moderate to good yields with high regio- and diastereoselectivity.
More Related Videos
Related Concept Videos
Cycloaddition Reactions: Overview
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Cycloaddition Reactions: MO Requirements for Thermal Activation


