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Electrochemical Dehydration of Sulfonic Acids to Their Anhydrides
Enrico Lunghi1, Annemijn M van Koten1, Johannes Schneider2
1Max-Planck-Institute for Chemical Energy Conversion (MPI CEC), Stiftstraße 34-36, Mülheim an der Ruhr 45470, Germany.
Abstract:
We developed an electrochemical method for sulfonic anhydride synthesis and one-pot derivatization into sulfonamides and mesylates under mild conditions. Aliphatic sulfonic anhydrides were electrogenerated in up to a 74% yield. Since isolating these moisture-sensitive intermediates is challenging, the in situ-generated sulfonic anhydrides were directly converted into sulfonamides or alkyl sulfonates using amines or alcohols, respectively. This scalable process enables the synthesis of various nitrogen- and oxygen-based products in the multigram range.
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