Crosstalk Between Microbiome and Ferroptosis in Diseases: From Mechanism to Therapy

Area of Science:

• Microbiology
• Cell Biology
• Immunology

Background:

• The human microbiome, a complex ecosystem, plays vital roles in host health, including immune function and nutrient processing.
• Microbiome alterations, termed dysbiosis, are linked to numerous diseases.
• Ferroptosis, a distinct form of cell death driven by iron, involves oxidative stress and lipid peroxidation.

Purpose of the Study:

• To systematically investigate the intricate relationship between the microbiome and ferroptosis across diverse diseases.
• To elucidate the mechanisms by which the microbiome influences ferroptosis.
• To explore the therapeutic potential of targeting microbiome-ferroptosis interactions.

Main Methods:

• Systematic review and analysis of existing literature on microbiome-ferroptosis associations.
• Exploration of pathways including host iron homeostasis, mitochondrial function, and lipid peroxidation.
• Investigation of both gut and oral microbiome influences on disease progression.

Main Results:

• The microbiome significantly impacts ferroptosis through various mechanisms, including regulation of iron metabolism and oxidative stress.
• Dysbiosis is associated with altered ferroptosis pathways in multiple disease contexts.
• Both gut and oral microbiomes demonstrate influence over disease progression via ferroptosis regulation.

Conclusions:

• The crosstalk between the microbiome and ferroptosis is a critical factor in disease pathogenesis.
• Understanding these interactions provides novel avenues for therapeutic interventions.
• Targeting the microbiome-ferroptosis axis holds promise for treating a range of human diseases.