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Updated: Sep 10, 2025

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
[Changes in renal function parameters after cotrimoxazole therapy]
John Michael Hoppe1, Martin Klaus2, Matthias Auer1
1Zentrale Notaufnahme Klinikum Innenstadt, LMU Klinikum, Ludwig-Maximilians-Universität München, Ziemssenstraße 5, 80336, München, Deutschland.
None:
Cotrimoxazole is a combination antibiotic composed of the two active substances trimethoprim and sulfamethoxazole (TMP-SMX). TMP-SMX is known to affect renal function parameters. It can cause true acute kidney injury but may also mimic acute kidney injury by inhibiting the renal secretion of creatinine. The present case demonstrates a significant increase in creatinine and urea levels, along with a reduced glomerular filtration rate, while cystatin C levels remained unchanged, representing an extent of alteration not previously reported in this form.
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