Evaluation of the Relationship Between Intake of Proton Pump Inhibitors and Peri-Implant Bone Microstructure by Using...

Area of Science:

• Oral and Maxillofacial Surgery
• Bone Metabolism Research
• Radiology

Background:

• Proton pump inhibitors (PPIs) are commonly used medications.
• Previous research suggests PPIs may impact bone metabolism and osseointegration.
• The long-term effects of PPIs on bone around dental implants require further investigation.

Purpose of the Study:

• To evaluate the long-term influence of PPI usage on trabecular bone patterns surrounding dental implants.
• To utilize fractal analysis of periapical radiographs to assess bone quality.

Main Methods:

• A retrospective, matched case-control study design was employed.
• The study included 54 patients (27 PPI users, 27 nonusers) with 175 dental implants.
• Outcome measures included implant survival, crestal bone loss (CBL), and fractal dimension (FD) assessed via radiographs.

Main Results:

• No significant difference in implant survival or crestal bone loss was found between PPI users and nonusers.
• A statistically significant difference in fractal dimension (FD) values was observed, with PPI users exhibiting lower FD.
• Lower FD values in PPI users suggest potentially compromised trabecular bone structure.

Conclusions:

• Proton pump inhibitor use may be associated with detrimental effects on bone metabolism around dental implants.
• Fractal analysis reveals alterations in trabecular bone patterns in PPI users.
• Clinicians should consider potential impacts on jawbone quality in patients on PPI therapy.