The Myopic Control Effect of Defocus Incorporated Multiple Segments' Spectacle Lens With Atropine in High Myopia...

Area of Science:

• Ophthalmology
• Pediatric Optometry
• Myopia Control

Background:

• High myopia in children poses significant risks for future ocular health.
• Current myopia control strategies include atropine (ATR) monotherapy and specialized spectacle lenses.
• Investigating combined therapies is crucial for optimizing myopia management.

Purpose of the Study:

• To compare the efficacy of combined atropine (ATR) and defocus incorporated multiple segments (DIMS) spectacle lenses versus ATR monotherapy in controlling high myopia progression in children.
• To evaluate the impact on spherical equivalent refraction (SER) and axial length (AXL) elongation over one year.

Main Methods:

• Retrospective cohort study including 35 eyes treated with ATR monotherapy and 32 eyes with ATR and DIMS lenses.
• Primary outcomes: SER progression and AXL elongation over a one-year follow-up.
• Statistical analysis using independent t-tests and generalized linear models.

Main Results:

• The combined ATR and DIMS group showed significantly less SER progression (-0.15±0.09D) compared to the ATR monotherapy group (-0.38±0.14D) (p<0.001).
• AXL elongation was also significantly lower in the combined group (0.06±0.04 mm) versus the ATR group (0.13±0.07 mm) (p<0.001).
• Younger age, higher baseline SER, and longer AXL were associated with greater progression in the ATR group, while higher baseline SER and AXL were independently associated with progression in the combined group.

Conclusions:

• Combined ATR and DIMS spectacle lenses are more effective in slowing myopia progression than ATR monotherapy in children with high myopia.
• This combination approach represents a potentially superior strategy for managing high-risk pediatric myopia.
• Further research into combined therapeutic modalities is warranted.