The Myopic Control Effect of Defocus Incorporated Multiple Segments' Spectacle Lens With Atropine in High Myopia...

This study investigated the efficiency of combined atropine (ATR) and defocus incorporated multiple segments' (DIMS) spectacle lens versus ATR monotherapy in controlling high myopia in children.

A retrospective cohort study was performed, enrolling patients treated with either ATR monotherapy (n=35 eyes) or a combination of ATR and DIMS lenses (n=32 eyes). The primary outcomes were the spherical equivalent refraction (SER) progression and axial length (AXL) elongation, and were measured over a one year follow up period. Statistical comparisons were made using independent t-tests and generalized linear models.

After one year, the ATR group showed significantly greater SER progression (-0.38±0.14D) compared to the DIMS-ATR group (-0.15±0.09D) (p<0.001). After the same period of time, AXL elongation was also significantly higher in the ATR group (0.13±0.07 mm) compared to the DIMS-ATR group (0.06±0.04 mm) (p<0.001). Subgroup analysis indicated that a young initial age, high baseline SER, and longer initial AXL were associated with greater SER progression and AXL elongation in the ATR group (all p<0.05). In addition, in the DIMS-ATR group, higher initial SER and AXL were independently associated with SER progression and AXL elongation, respectively (both p<0.05).

The combined ATR plus DIMS spectacle lenses was more effective in slowing myopia progression than ATR monotherapy in children with high myopia. This combined approach may be a preferable strategy for managing high-risk pediatric myopia.