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Updated: Sep 9, 2025
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Circadian Rhythm and Muscle Function
Hyeon-Ki Kim1,2, Shigenobu Shibata3,4
1National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Advances in Experimental Medicine and Biology
|August 29, 2025
Summary
Regular life rhythms are crucial for health, with internal body clocks regulating skeletal muscle function. Exercise impacts this clock, influencing muscle performance and timing.
Area of Science:
- Chronobiology
- Skeletal Muscle Physiology
- Exercise Science
Background:
- The discovery of clock genes in mammals has elucidated the physiological role of the internal body clock, a ~24-hour rhythm essential for health.
- Skeletal muscle function is significantly influenced by this internal clock, with over 2300 genes exhibiting circadian rhythms involved in myogenesis, transcription, and metabolism.
Purpose of the Study:
- To explore the regulatory role of the internal clock in skeletal muscle function.
- To investigate the effects of exercise on the skeletal muscle internal clock.
- To discuss the potential timing effects of exercise on skeletal muscle.
Main Methods:
- Literature review on circadian rhythms in skeletal muscle.
- Analysis of gene expression patterns related to circadian regulation in muscle.
- Discussion of exercise interventions and their impact on the muscle clock.
Main Results:
- The internal clock regulates key skeletal muscle functions, including myogenesis, transcription, and metabolism.
- A significant number of genes (>2300) in skeletal muscle show circadian rhythmicity.
- Exercise is identified as a factor that can modulate the skeletal muscle internal clock.
Conclusions:
- Maintaining a regular life rhythm is vital for skeletal muscle health.
- The skeletal muscle internal clock plays a critical role in physiological processes.
- Exercise can influence the timing and regulation of the skeletal muscle clock, with implications for performance and health.
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