Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

123
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
123
Cross-bridge Cycle01:26

Cross-bridge Cycle

118.2K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
118.2K
Understanding Sleep01:11

Understanding Sleep

502
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
502
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.6K
Relaxation of Skeletal Muscles01:29

Relaxation of Skeletal Muscles

3.7K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrinsic exercise capacity is associated with skeletal muscle clock gene and IGF-1 signaling in aged low- and high-running capacity rats.

Frontiers in physiology·2026
Same author

Mealtime irregularity is associated with higher serum growth differentiation factor-15 levels in older adults: the explanatory role of dietary quality.

European geriatric medicine·2026
Same author

Acute and Second-Meal Effects of Oat Products on Postprandial Glucose Responses in Healthy Japanese Adults: A Randomized Crossover Pilot Study.

Food science & nutrition·2026
Same author

Association between mealtime regularity and breakfast frequency with postpartum depression in first-time Japanese mothers: a cross-sectional study.

BMC pregnancy and childbirth·2026
Same author

Time-of-day difference in iron supplementation in iron-deficient pregnant model mice.

NPJ science of food·2026
Same author

Associations of Temporal Eating Patterns with Nutrient Intake Variability and Diet Quality Among Japanese Female Mobile Application Users.

Nutrients·2026
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Sep 9, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Circadian Rhythm and Muscle Function.

Hyeon-Ki Kim1,2, Shigenobu Shibata3,4

  • 1National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan.

Advances in Experimental Medicine and Biology
|August 29, 2025
PubMed
Summary
This summary is machine-generated.

Regular life rhythms are crucial for health, with internal body clocks regulating skeletal muscle function. Exercise impacts this clock, influencing muscle performance and timing.

Keywords:
Chrono-exerciseCircadian rhythmMuscle clockMuscle function

More Related Videos

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.9K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K

Related Experiment Videos

Last Updated: Sep 9, 2025

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

9.9K
Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

12.1K

Area of Science:

  • Chronobiology
  • Skeletal Muscle Physiology
  • Exercise Science

Background:

  • The discovery of clock genes in mammals has elucidated the physiological role of the internal body clock, a ~24-hour rhythm essential for health.
  • Skeletal muscle function is significantly influenced by this internal clock, with over 2300 genes exhibiting circadian rhythms involved in myogenesis, transcription, and metabolism.

Purpose of the Study:

  • To explore the regulatory role of the internal clock in skeletal muscle function.
  • To investigate the effects of exercise on the skeletal muscle internal clock.
  • To discuss the potential timing effects of exercise on skeletal muscle.

Main Methods:

  • Literature review on circadian rhythms in skeletal muscle.
  • Analysis of gene expression patterns related to circadian regulation in muscle.
  • Discussion of exercise interventions and their impact on the muscle clock.

Main Results:

  • The internal clock regulates key skeletal muscle functions, including myogenesis, transcription, and metabolism.
  • A significant number of genes (>2300) in skeletal muscle show circadian rhythmicity.
  • Exercise is identified as a factor that can modulate the skeletal muscle internal clock.

Conclusions:

  • Maintaining a regular life rhythm is vital for skeletal muscle health.
  • The skeletal muscle internal clock plays a critical role in physiological processes.
  • Exercise can influence the timing and regulation of the skeletal muscle clock, with implications for performance and health.