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Updated: Sep 9, 2025

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Muscle Disuse Atrophy.

Dongwook Yeo1

  • 1Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Yeo.Dongwook@mayo.edu.

Advances in Experimental Medicine and Biology
|August 29, 2025
PubMed
Summary
This summary is machine-generated.

Muscle disuse atrophy, a loss of muscle mass and strength from inactivity, affects many patients. Research explores molecular mechanisms and new therapies beyond resistance training to combat this condition.

Keywords:
AutophagyMitochondriaMuscle atrophyPgc-1alphaUbiquitin proteasome

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Area of Science:

  • Physiology
  • Molecular Biology
  • Gerontology

Background:

  • Muscle disuse atrophy involves skeletal muscle mass and strength reduction due to inactivity.
  • It is common in patients with limb immobilization or spinal cord injuries, worsened by age and poor nutrition.
  • Rodent models like hindlimb unloading have advanced understanding of muscle degradation mechanisms.

Purpose of the Study:

  • To summarize molecular and cellular pathways driving muscle catabolism during disuse.
  • To review current and emerging therapeutic strategies for muscle disuse atrophy.
  • To highlight the impact of muscle wasting on quality of life and physical function.

Main Methods:

  • Review of rodent models (hindlimb unloading, immobilization, denervation, spinal cord isolation).
  • Analysis of molecular and cellular mechanisms of muscle protein breakdown.
  • Synthesis of existing literature on resistance training and novel therapeutic interventions.

Main Results:

  • Detailed understanding of molecular signals and pathways causing muscle wasting.
  • Identification of resistance training as effective but limited for some patients.
  • Emerging pharmacological and non-pharmacological strategies show promise for prevention and recovery.

Conclusions:

  • Muscle disuse atrophy has complex molecular underpinnings and significant clinical impact.
  • Current therapies are limited, necessitating research into alternative treatments.
  • Future strategies aim to prevent atrophy or enhance recovery, improving patient outcomes and quality of life.