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Lifestyle Interventions in Frailty.
Fernando Millan-Domingo1, Jose Viña2
1Department of Physiology, Faculty of Medicine, University of Valencia, Valencia, Spain.
Advances in Experimental Medicine and Biology
|August 29, 2025
Summary
Frailty in older adults can be prevented and reversed through personalized nutrition and exercise interventions. Tailoring these lifestyle changes is key to combating age-associated frailty and reducing disability.
Area of Science:
- Gerontology and Geriatrics
- Lifestyle Medicine
Background:
- Frailty is a significant concern in aging populations, leading to increased disability and care dependency.
- Current projections indicate a substantial rise in the elderly population requiring care by 2050.
- Unlike aging, frailty is a condition that can be addressed and potentially reversed.
Purpose of the Study:
- To review the roles of nutrition and physical exercise in preventing and treating age-associated frailty.
- To emphasize the critical need for personalized interventions in gerontology and geriatrics.
- To outline general, yet adaptable, strategies for managing frailty.
Main Methods:
- Review of current literature on lifestyle interventions for frailty.
- Analysis of the principles of personalized medicine applied to geriatric care.
- Synthesis of general approaches for tailored nutrition and exercise programs.
Main Results:
- Nutrition and physical exercise are identified as primary lifestyle interventions for frailty.
- Personalization is a common characteristic crucial for the effectiveness of both nutrition and exercise interventions.
- The review highlights the potential for precision interventions in geriatrics, mirroring advances in other fields like oncology.
Conclusions:
- Age-associated frailty is a modifiable condition that can be prevented or reverted.
- Personalized nutrition and exercise are effective strategies for managing frailty.
- A shift towards precision, individualized interventions is essential for advancing geriatric care and improving outcomes for older adults.
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