Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

752
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
752
Epigenetic Regulation01:37

Epigenetic Regulation

3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.1K
Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

1.9K
Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...
1.9K
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

1.9K
Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
1.9K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.0K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
2.0K
Overview of Muscle Tissues01:25

Overview of Muscle Tissues

13.2K
The human body has three types of muscle tissue: skeletal, smooth, and cardiac. Each class has unique properties that enable them to perform specific functions. However, all muscle tissues share certain properties, including elasticity, contractility, and excitability. 
Elasticity
Elasticity is the ability of muscles to stretch and return to their original shape. This property is partly due to elastic fibers — macromolecules that run through the muscles. These fibers are firm and...
13.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SpillOver stimulation: A novel hypertrophy model using co-contraction of the plantar-flexors to load the tibial anterior muscle in rats.

PloS one·2018
Same author

A novel miniature in-line load-cell to measure in-situ tensile forces in the tibialis anterior tendon of rats.

PloS one·2017
Same author

Congestive heart failure: experimental model.

Frontiers in pediatrics·2014
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Sep 9, 2025

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle
09:30

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle

Published on: November 6, 2017

8.7K

Muscle Plasticity, Adaptation and Epigenetics.

Jonathan Charles Jarvis1

  • 1School of Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK. J.C.Jarvis@ljmu.ac.uk.

Advances in Experimental Medicine and Biology
|August 29, 2025
PubMed
Summary
This summary is machine-generated.

Skeletal muscle adapts its phenotype to match activity demands, developing endurance or sprint characteristics. This remarkable cellular plasticity is crucial for athletic performance, aging, and metabolic health.

Keywords:
Exercise responseMuscle adaptationMuscle fibre typeMuscle trainingPlasticity

More Related Videos

Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants
06:53

Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants

Published on: October 15, 2019

17.6K
Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
10:22

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

Published on: September 8, 2023

1.7K

Related Experiment Videos

Last Updated: Sep 9, 2025

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle
09:30

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle

Published on: November 6, 2017

8.7K
Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants
06:53

Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants

Published on: October 15, 2019

17.6K
Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue
10:22

Author Spotlight: Investigating mRNA Spatial Distribution in Drosophila Muscle Tissue

Published on: September 8, 2023

1.7K

Area of Science:

  • Muscle physiology
  • Cellular adaptation
  • Neuromuscular science

Background:

  • Skeletal muscle exhibits significant phenotypic plasticity in adult cells.
  • Muscle fibers adapt to changes in activity patterns, influencing gene expression and protein profiles.
  • This adaptation is influenced by hormonal signals and mechanical stimuli.

Purpose of the Study:

  • To review the historical evidence and experimental models of muscle phenotypic adaptation.
  • To highlight the molecular mechanisms underlying muscle response to altered activity.
  • To underscore the physiological significance of muscle adaptation in various contexts.

Main Methods:

  • Review of historical experimental data on muscle adaptation.
  • Integration of findings from transcriptomic, epigenomic, and proteomic analyses.
  • Focus on advancements in experimental models for studying neuromuscular physiology.

Main Results:

  • Demonstration of substantial phenotypic adaptation in differentiated adult muscle cells.
  • Identification of 'endurance' and 'sprint' phenotypes based on activity patterns.
  • Elucidation of multifaceted intracellular mechanisms driving muscle adaptation.

Conclusions:

  • Muscle phenotypic adaptation is a fundamental aspect of neuromuscular physiology.
  • Understanding these adaptations is vital for athletic training, managing age-related muscle loss, and metabolic health.
  • Progress in experimental models allows for deeper insights into this cellular plasticity.