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Updated: Sep 9, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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Circular RNAs and Cancers.
Mohammad Mahdi Heidari1,2,3, Mohammad Saeid Moeinfar2,3, Mahdi Rafiyan2,3
1Department of Pediatric, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Advances in Experimental Medicine and Biology
|August 31, 2025
Summary
Circular RNAs (circRNAs) are novel RNA molecules with crucial roles in cell function. Their abnormal presence in tumors drives cancer growth, offering potential as clinical biomarkers and therapeutic targets.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Circular RNAs (circRNAs) are endogenous RNA molecules formed by back-splicing of pre-mRNAs.
- They possess unique covalently closed circular structures.
- Emerging roles include microRNA sponging, protein scaffolding, and gene expression regulation.
Purpose of the Study:
- To examine advancements in circRNA research in cancer.
- To focus on their molecular mechanisms.
- To explore their clinical significance.
Main Methods:
- Review of current scientific literature on circRNAs in cancer.
- Analysis of molecular mechanisms underlying circRNA function in tumorigenesis.
- Evaluation of circRNAs as potential clinical biomarkers and therapeutic targets.
Main Results:
- Abnormal circRNA expression is linked to tumor progression.
- CircRNAs contribute to uncontrolled cell proliferation, invasion, and evasion of cell death.
- Dysregulated circRNAs play significant roles in various cancers.
Conclusions:
- CircRNAs are implicated in key cancer hallmarks.
- Their unique properties suggest potential as diagnostic markers.
- CircRNAs represent promising targets for novel cancer therapies.
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