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Updated: Sep 8, 2025

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Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence-Based Interventions.

Elizabeth Kream1, Sabrina G Fabi1, Monica Boen1

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|September 6, 2025
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Summary
This summary is machine-generated.

Introducing "skinspan," a new framework for skin healthspan. This review explores interventions like sun protection, retinoids, antioxidants, and emerging therapies to maintain youthful skin and promote long-term skin longevity.

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Area of Science:

  • Dermatology and Aesthetic Medicine
  • Regenerative Medicine and Geroscience

Background:

  • Focus in translational research has shifted from lifespan to healthspan.
  • The concept of "skinspan" is introduced to describe and guide long-term skin health and appearance.

Purpose of the Study:

  • To establish "skinspan" as a framework for long-term skin health.
  • To review molecular drivers of skin aging and evidence-based interventions.
  • To synthesize evidence into an algorithm for expanding skinspan.

Main Methods:

  • Comprehensive literature review on molecular hallmarks of skin aging (genomic instability, mitochondrial dysfunction, cellular senescence, proteostasis decline).
  • Appraisal of interventions: lifestyle modifications, pharmacologic agents, and aesthetic procedures.
  • Categorization of interventions based on evidence strength for augmenting skinspan.

Main Results:

  • Proactive interventions show promise in mitigating skin aging mechanisms.
  • Recommended first-line strategy: sun protection, topical retinoids, and antioxidants.
  • Second-line: laser and energy-based devices; third-line: emerging therapies (stem cells, sirtuins, nicotinamide).

Conclusions:

  • The skinspan framework offers a holistic, evidence-based approach to skin longevity.
  • Promotes prevention, continuity of care, and patient education beyond isolated aesthetic interventions.
  • Further randomized controlled trials are needed to strengthen the evidence base.