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Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence-Based Interventions
Elizabeth Kream1, Sabrina G Fabi1, Monica Boen1
1Cosmetic Laser Dermatology, San Diego, California, USA.
Journal of Cosmetic Dermatology
|September 6, 2025
Summary
Introducing "skinspan," a new framework for skin healthspan. This review explores interventions like sun protection, retinoids, antioxidants, and emerging therapies to maintain youthful skin and promote long-term skin longevity.
Area of Science:
- Dermatology and Aesthetic Medicine
- Regenerative Medicine and Geroscience
Background:
- Focus in translational research has shifted from lifespan to healthspan.
- The concept of "skinspan" is introduced to describe and guide long-term skin health and appearance.
Purpose of the Study:
- To establish "skinspan" as a framework for long-term skin health.
- To review molecular drivers of skin aging and evidence-based interventions.
- To synthesize evidence into an algorithm for expanding skinspan.
Main Methods:
- Comprehensive literature review on molecular hallmarks of skin aging (genomic instability, mitochondrial dysfunction, cellular senescence, proteostasis decline).
- Appraisal of interventions: lifestyle modifications, pharmacologic agents, and aesthetic procedures.
- Categorization of interventions based on evidence strength for augmenting skinspan.
Main Results:
- Proactive interventions show promise in mitigating skin aging mechanisms.
- Recommended first-line strategy: sun protection, topical retinoids, and antioxidants.
- Second-line: laser and energy-based devices; third-line: emerging therapies (stem cells, sirtuins, nicotinamide).
Conclusions:
- The skinspan framework offers a holistic, evidence-based approach to skin longevity.
- Promotes prevention, continuity of care, and patient education beyond isolated aesthetic interventions.
- Further randomized controlled trials are needed to strengthen the evidence base.
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