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Updated: Jan 18, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Synthesis, crystal structure and Hirshfeld surface analysis of ethyl
Irina A Kolesnik1, Artem P Sanchez-Pimentel2, Mikhail S Grigoriev3
1Institute of Physical Organic Chemistry of National Academy of Sciences of Belarus, 13 Surganov Str., 220072 Minsk, Belarus.
Abstract:
In the mol-ecule of the title compound, C17H16N2O3, the isoxazol and phenyl rings are oriented at a dihedral angle of 14.84 (5)°. The 2-cyano-acrylate moiety is in E- configuration. In the crystal, there are no inter-molecular hydrogen-bonding or C-H⋯π(ring) inter-actions, only a π-π inter-action between the parallel isoxazol rings with centroid-to-centroid distance of 3.4932 (9) Å (α = 0.02°). The Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H⋯H (43.9%), H⋯N/N⋯H (17.0%), H⋯O/O⋯H (13.9%) and C⋯C (10.1%) inter-actions.
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