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Preparation and osteogenic properties of degradable pectin-modified magnesium oxychloride bone cement
Jinlun Feng1, Yijia Guan1, Tingting Ma1
1Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, China.
Abstract:
A novel biodegradable bone cement (PSM) was successfully developed through the modification of magnesium oxychloride cement (MOC) with pectin, specifically addressing the inherent limitation of poor water resistance in conventional MOC. Properties of PSM such as washout resistance, setting time, mechanical properties and degradation properties were investigated. Results showed that PSM with 1.5 wt% pectin (1.5 PSM) has a short setting time, a long degradation time, good anti-washout resistance, and good resistance to water. In addition to that, the 1.5 PSM had good degradation properties, cytocompatibility, and could promote the formation of new bone tissue. The 1.5 PSM exhibits good apatite formation ability when immersed in simulated body fluids. According to the MTT assay and live/dead cell staining results, it exhibits good cytocompatibility. After the implantation in rat femur, 1.5 PSM had a more excellent bone and angiogenic ability. Thus, the 1.5 PSM was expected to be used as a new artificial bone repair material.
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