Related Experiment Video
Updated: Jan 18, 2026
12:56
Seeded Synthesis of CdSe/CdS Rod and Tetrapod Nanocrystals
Published on: December 11, 2013
40.3K
Green Synthesis of Selenium Nanoparticles by Grape Seed Extract Synergized with Ascorbic Acid: Preparation
Hua Cheng1,2, Li Wang1,2, Shuqing Jia1,2
1School of Modern Industry for Selenium Science and Engineering, Wuhan Polytechnic University, Wuhan 430048, China.
Foods (Basel, Switzerland)
|September 13, 2025
Summary
Green synthesis of selenium nanoparticles (SeNPs) using grape seed extract and ascorbic acid yielded stable, small nanoparticles. These functional nanomaterials show promise for food preservation and safety due to antioxidant and antibacterial properties.
Area of Science:
- Nanotechnology
- Green Chemistry
- Materials Science
Background:
- Selenium nanoparticles (SeNPs) offer significant potential in food preservation and drug development.
- Developing stable and effective SeNPs requires optimized synthesis methods.
- Natural compounds are increasingly explored for eco-friendly nanoparticle synthesis.
Purpose of the Study:
- To achieve green synthesis of selenium nanoparticles (SeNPs) using grape seed extract (GSE) and ascorbic acid (Vc).
- To optimize synthesis conditions for small particle size, good dispersibility, and low PDI.
- To characterize the synthesized GSE-SeNPs and evaluate their biological activities.
Main Methods:
- Green synthesis of SeNPs using GSE as a reducing agent and stabilizer, with Vc.
- Optimization of synthesis parameters (Vc and GSE concentrations, time, temperature) using Response Surface Methodology (RSM).
- Characterization of SeNPs using particle size analysis, PDI, Zeta potential, and structural analysis.
Main Results:
- Optimized synthesis yielded stable GSE-SeNPs with an average particle size of 74.86 ± 6.07 nm and a PDI of 0.159 ± 0.028.
- Zeta potential of -30.42 ± 0.54 mV indicated good colloidal stability.
- Characterization confirmed spherical nanoparticles with a dense structure and organic coating from GSE, demonstrating DPPH free radical scavenging and antibacterial activity against *Staphylococcus aureus*.
Conclusions:
- GSE-SeNPs were successfully synthesized via a green chemistry approach.
- The synthesized nanoparticles exhibit excellent stability and desirable physicochemical properties.
- GSE-SeNPs possess significant antioxidant and antibacterial activities, highlighting their potential as functional nanomaterials for food preservation and safety.
