Advanced vs. Standard Monofocal IOLs: Optical Quality and Patient-Perceived Visual Outcomes.

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Optics

Background:

• Cataract surgery requires intraocular lens (IOL) implantation to restore vision.
• Monofocal IOLs offer corrected distance vision but may have limitations in intermediate or near vision.
• Advanced IOL designs aim to improve visual quality and patient satisfaction.

Purpose of the Study:

• To compare the optical and visual quality of the ISOPure advanced monofocal IOL versus the MicroPure standard monofocal IOL.
• To evaluate both objective optical metrics and subjective patient-reported outcomes.

Main Methods:

• Prospective, single-blind study of 28 cataract patients with bilateral IOL implantation (ISOPure or MicroPure).
• Visual acuities (UDVA, UIVA, CDVA, DCIVA) measured under photopic and mesopic conditions.
• Objective optical quality assessed via OSI, MTF, SR, and aberrations; subjective quality via QoV and Catquest-9SF questionnaires.

Main Results:

• ISOPure demonstrated statistically better corrected intermediate visual acuity (DCIVA) at 80 cm and 66 cm under photopic conditions (p=0.05, p=0.02).
• No significant differences in halo/glare, OSI, MTF, or SR were found between the IOLs.
• ISOPure showed significant differences in higher-order aberrations and led to greater patient satisfaction and functional intermediate vision.

Conclusions:

• The ISOPure IOL provides superior intermediate vision compared to the MicroPure IOL.
• ISOPure offers a balanced profile of optical quality, functional performance, and patient satisfaction.
• This advanced monofocal IOL may be a beneficial option for cataract patients seeking improved intermediate visual function.