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Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

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Published on: February 24, 2021

Direction of motion decoding in mouse V1: Neuron predictive power relates to functional connectivity organization.

Mario Alexios Savaglio^1,2, Christina Brozi^1,2, Eleftheria Psilou^1,2

¹Department of Computer Science, University of Crete, Greece.

Biorxiv : the Preprint Server for Biology

|September 15, 2025

Summary

High predictive power (HPP) neurons in the mouse visual cortex are crucial for decoding visual motion. These neurons show distinct network activity during stimulation versus resting states, revealing coordinated processing essential for behavior.

Keywords:

area V1 direction of motion functional connectivity neuronal ensembles stimulus decoding

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Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Single neuron variability complicates visual stimulus representation.
Integrating multi-neuron responses enhances accuracy for behaviorally relevant stimuli.
The primary visual cortex (V1) is key for initial visual processing.

Purpose of the Study:

To investigate the role of high predictive power (HPP) neurons in decoding visual motion direction.
To characterize the functional connectivity and activity patterns of HPP neurons during visual stimulation and resting states.
To understand how HPP neurons contribute to information processing in the mouse V1.

Main Methods:

In vivo mesoscopic 2-photon calcium imaging of mouse V1.
Presentation of 16 distinct visual motion directions as stimuli.
Mutual information analysis to identify HPP neurons.
Analysis of neuronal firing rates and functional connectivity.

Main Results:

HPP neurons exhibit elevated firing rates and denser, stronger functional connectivity during visual stimulation.
Functional connections among HPP neurons are distance-independent, suggesting a distributed network.
During resting state, HPP neurons show lower activity and connectivity, differing from other visually responsive neurons.
HPP neurons display diverse tuning properties, with some sharply tuned and others broadly tuned yet informative.

Conclusions:

HPP neurons form a critical, coordinated network for visual motion decoding in mouse V1.
The distinct activity patterns of HPP neurons in stimulus vs. resting states highlight their specialized role.
These findings advance our understanding of neural ensemble organization and information processing in the visual cortex.