Related Experiment Video
Updated: May 13, 2026

20:28
A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments
Published on: October 2, 2012
14.6K
A fluorogenic probe for screening aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors
Shilpendu Ghosh1, Sayar Ghosh2, Aniket Majee1
1Department of Chemical Sciences and Centre for Advanced Functional Materials (CAFM), Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, Mohanpur 741246, India. a.mukherjee@iiserkol.ac.in.
Abstract:
We report the first competitive aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor featuring a fluorogenic binding response and nanomolar affinity (KD), enabling real-time screening of non-fluorescent inhibitors with high cellular compatibility and no observed toxicity.

