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Updated: Jan 17, 2026

A Structured Approach to Extubation in Mechanically Ventilated Rats
Published on: July 18, 2025
Lower non-invasive estimated Pmus predicts extubation failure in mechanically ventilated ICU patients
Graziela Müller1, Manoela Bonato Zocoli1, Jéssica Magnante1,2
1Universidade do Oeste de Santa Catarina, Joaçaba, Santa Catarina, Brasil.
Abstract:
We evaluated whether non-invasive estimated inspiratory muscle pressure (Pmus) predicts extubation outcomes in ICU patients. Estimated Pmus, reflecting the pressure generated by respiratory muscles, was measured before and after the spontaneous breathing trial (SBT). Lower pre-SBT estimated Pmus (<4.1 cmH₂O) and post-SBT (<4.4 cmH₂O) were associated with extubation failure (AUC ≈ 0.73). P0.1 and dynamic transpulmonary pressure (PL,dyn) showed no significant association. Estimated Pmus offers a simple bedside method to assess inspiratory muscle strength and may help identify patients at risk of extubation failure. Further multicenter studies are needed to validate these findings.
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