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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

982
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Related Experiment Video

Updated: Jan 16, 2026

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
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Probiotic-Based Materials as Living Therapeutics.

Laura Sabio1, Graham J Day1, Manuel Salmeron-Sanchez1,2,3

  • 1Centre for the Cellular Microenvironment (CeMi), University of Glasgow, University Avenue, Glasgow, G12 8QQ, United Kingdom.

Advanced Materials (Deerfield Beach, Fla.)
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Engineered Living Materials (ELMs), specifically Probiotic Living Materials (PLMs), offer targeted therapies but require improved genetic tools and safety regulations for clinical use. Addressing these challenges will unlock PLMs' full potential in various biomedical applications.

Keywords:
engineered living materialsprobioticstherapeutics

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Area of Science:

  • Biomaterials Science
  • Synthetic Biology
  • Microbiology

Background:

  • Advanced biomaterials are crucial for developing safer, targeted therapeutics.
  • Engineered Living Materials (ELMs), integrating synthetic biology and material science, show promise for biomedical applications.
  • Probiotic Living Materials (PLMs) are a subclass of ELMs using engineered probiotics within matrices, distinct from Living Biotherapeutic Products (LBPs).

Purpose of the Study:

  • To review the fundamental features of ELMs and probiotics.
  • To explore recent advances in engineered PLMs for biomedical applications.
  • To discuss biosafety concerns and regulatory gaps for PLM clinical implementation.

Main Methods:

  • Literature review of Engineered Living Materials (ELMs) and Probiotic Living Materials (PLMs).
  • Analysis of recent studies on PLM design and applications.
  • Examination of biosafety considerations and regulatory frameworks.

Main Results:

  • PLMs demonstrate potential in biosensing, infection treatment, bone repair, wound healing, vaginal imbalances, gut conditions, and cancer therapy.
  • Significant challenges remain, including limited genetic engineering tools for probiotics.
  • Biosafety concerns like horizontal gene transfer and regulatory hurdles impede clinical translation.

Conclusions:

  • PLMs offer dynamic and targeted therapeutic strategies.
  • Robust genetic toolkits and clear regulatory pathways are essential for safe and effective clinical translation of PLMs.
  • Further research is needed to overcome current limitations, especially for vulnerable populations.