Sustainable Durian Rind Carboxymethyl Cellulose/Poly(vinyl) Alcohol Hydrogels Synthesis for Enhancing Crosslinking...

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Sustainable Chemistry

Background:

• Durian rind is an abundant agricultural waste, rich in cellulose.
• Developing novel biomaterials from renewable resources is crucial for sustainability.
• Carboxymethyl cellulose (CMC) and poly(vinyl) alcohol (PVA) are widely used in biomedical applications.

Purpose of the Study:

• To develop novel hydrogels from durian rind-derived CMC blended with PVA.
• To investigate the effect of NaOH concentration on CMC properties and hydrogel crosslinking.
• To evaluate the potential of these hydrogels for wound dressings and controlled drug delivery.

Main Methods:

• Durian rind was processed into carboxymethyl cellulose (CMCd) with varying degrees of substitution (DS).
• CMC-30, derived using 30% NaOH, was blended with PVA and crosslinked using citric acid.
• Hydrogel properties including swelling ratio, crosslinking efficiency, and methylene blue release were analyzed.

Main Results:

• CMCd-30 exhibited a high yield (230.96%) and DS (0.94).
• The CMCd-30/PVA hydrogel showed maximum crosslinking efficiency (86.16%) and a high swelling ratio (125.54%).
• Methylene blue release was sustained up to 1440 minutes, indicating controlled drug delivery capabilities.

Conclusions:

• Durian rind-derived CMC/PVA hydrogels are promising sustainable biomaterials.
• These hydrogels demonstrate excellent water absorption and functional group availability for biomedical uses.
• The developed hydrogels show significant potential for applications in wound dressings and controlled drug delivery systems.