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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
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Polymer Network-Based Nanogels and Microgels: Design, Classification, Synthesis, and Applications in Drug Delivery.

Sabuj Chandra Sutradhar1, Nipa Banik1, Gazi A K M Rafiqul Bari2

  • 1Department of Energy Materials Science and Engineering, Konkuk University, 268 Chungwon-aero, Chungju-si 27478, Republic of Korea.

Gels (Basel, Switzerland)
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Polymer nanogels (NGs) and microgels (MGs) offer tunable drug delivery platforms. This review details their design, synthesis, characterization, and applications in treating diseases like cancer and infections.

Keywords:
drug deliverymicrogelsnanogelspersonalized medicinestimuli-responsive polymerstheranostics

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Polymer network-based nanogels (NGs) and microgels (MGs) are versatile platforms for advanced drug delivery.
  • Their tunable architecture, biocompatibility, and stimuli-responsiveness make them promising for therapeutic applications.

Purpose of the Study:

  • To provide a comprehensive analysis of nanogels and microgels for drug delivery.
  • To cover their classification, synthesis, characterization, and applications.
  • To discuss future directions and translational challenges.

Main Methods:

  • Classification based on polymer origin, crosslinking, composition, charge, stimuli-responsiveness, and architecture.
  • Detailed synthesis strategies including inverse microemulsion and radiation-induced polymerization.
  • Highlighting key characterization techniques for physicochemical and functional properties.

Main Results:

  • Emphasis on design-driven applications for overcoming biological barriers and targeted therapies (cancer, inflammation, diabetes, viral infections).
  • Discussion of multifunctional nanogels for theranostics, immunotherapy, and personalized medicine.
  • Identification of translational challenges such as scalable manufacturing and regulatory considerations.

Conclusions:

  • Nanogels and microgels are advanced platforms with significant potential in drug delivery and targeted therapies.
  • Further research and development are needed to address manufacturing and regulatory hurdles for clinical translation.
  • This review serves as a foundational resource for developing next-generation therapeutics.