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Related Concept Videos

General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Transcription Factors02:16

Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Regulation of Expression Occurs at Multiple Steps02:24

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Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
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Regulation of Expression Occurs at Multiple Steps02:24

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Exceptions to Broad Tissue-Specific Transcriptomic Interdependence: Searching for Independence in Expression of

Mikołaj Danielewski1,2, Jarosław Walkowiak1, Karolina Wielgus1

  • 1Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna 27/33, 60-572 Poznan, Poland.

Genes
|September 27, 2025
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Summary
This summary is machine-generated.

Genes with Independent In Expression (INDIE) patterns were identified across tissues. Some INDIE genes, like HIST1H2AD and TMEM176B, replicated in external datasets, suggesting potential roles in biomarkers and gene regulation.

Keywords:
bloodcorrelationexpressiongeneileumindependenttissuetranscriptomeuncorrelated

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Area of Science:

  • Genomics
  • Gene Expression Analysis
  • Bioinformatics

Background:

  • Gene correlation within tissues is well-studied.
  • Genes with Independent In Expression (INDIE) patterns are poorly understood.
  • INDIE genes may indicate tissue admixtures or novel regulatory mechanisms.

Purpose of the Study:

  • To identify INDIE genes across various human tissues.
  • To investigate the replicability of INDIE genes in external datasets.
  • To explore the potential of INDIE genes as biomarkers.

Main Methods:

  • Calculated biweight midcorrelation for gene pairs in GTEx v8 dataset.
  • Defined INDIE genes using absolute (r) and relative (Z-score) thresholds.
  • Validated INDIE gene findings in external whole blood and ileum datasets.

Main Results:

  • One gene, RPL13P12, was INDIE across all GTEx tissues but lacked external validation.
  • HIST1H2AD and TMEM176B were INDIE in GTEx whole blood and replicated across four external datasets.
  • ACAT2 and HBB showed replication in external ileal datasets, highlighting tissue heterogeneity's role.

Conclusions:

  • Described a set of genes with independent expression patterns across GTEx tissues.
  • External validation confirmed specific INDIE genes, such as HIST1H2AD and TMEM176B.
  • Findings suggest both tissue heterogeneity and novel gene expression regulatory mechanisms contribute to INDIE patterns.