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Published on: April 19, 2019
Synthesis of N-Sulfonyl Acetamidine Using Calcium Carbide as the Alkynyl Source and Ammonium Bicarbonate as the Amine
Rui An1, Peiming Gu1, Meng-Xue Wei1
1Ningxia Research Center for Natural Medicine Engineering and Technology, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
Abstract:
A new approach for the efficient synthesis of N-sulfonyl acetamidine via a one-pot multicomponent reaction at room temperature using calcium carbide as the alkyne source and ammonium bicarbonate as the amine source with sulfonyl azides is reported. The method efficiently constructed two bonds (C-N and C═N) in the aqueous system and has the advantages of cheap and easy availability of raw materials, mild conditions, simple operation, wide scope of substrates, convenient scale-up to gram scale, and potential industrial applications.
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