Phenotype-guided approach for device-based therapies in heart failure

Area of Science:

• Cardiology
• Biomedical Engineering

Background:

• Device-based therapies are crucial for heart failure (HF) management, offering benefits beyond pharmacologic treatments.
• Current device selection lacks a tailored framework, leading to underutilization of effective therapies in eligible patients.
• Addressing this gap can maximize therapeutic benefits for the diverse HF population.

Purpose of the Study:

• To review the current role of device-based HF therapies based on clinical trial evidence.
• To propose a phenotype-driven framework for guiding device selection in HF patients.
• To identify future directions for improving HF care through device therapy.

Main Methods:

• Literature review of clinical trials on device-based HF therapies.
• Development of a phenotype-driven framework for device selection.
• Analysis of HF patient profiles, including reduced and preserved ejection fraction.

Main Results:

• Device therapies play an integral role in managing heart failure.
• A comprehensive, phenotype-driven framework for device selection is proposed.
• The framework aims to guide clinicians in choosing optimal devices for individual HF patients.

Conclusions:

• A structured approach to device selection can enhance heart failure management.
• The proposed framework addresses the need for personalized device therapy in HF.
• Future research should focus on refining device strategies to improve patient outcomes.