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Updated: Jan 15, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-[(4-Amino-phen-yl)sulfan-yl]aniline
Rao M Uppu1, Ogad A Agu2, Patrick F Mensah2
1Department of Environmental Toxicology Southern University and A&M College Baton Rouge Louisiana 70813 USA.
Abstract:
The redetermined structure of the title compound, C12H12N2S, was refined from low-temperature (100 K) single-crystal X-ray diffraction data. Although achiral, the compound crystallizes in Sohncke space group P212121 in a chiral conformation distorted from idealized C 2 symmetry and the dihedral angle between the phenyl groups is 72.01 (7)°. In the extended structure, the NH2 substituents participate in N-H⋯S, N-H⋯N, and N-H⋯π inter-actions, leading to a three-dimensional hydrogen-bonded array. These results highlight the role of sulfur bridges in tuning packing inter-actions relevant to polymer design.
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