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Updated: Jan 15, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
Divergent late stage functionalisation of luminescent europium(III) complexes for targeting and imaging applications
Tsz-Lam Cheung1, Carlson Alexander1, Huishan Li1
1Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, 999077, Hong Kong SAR, China. davidparker@hkbu.edu.hk.
Abstract:
An efficient approach to six functionalised europium(III) complexes based on a common alkyne intermediate is exemplified by syntheses with morpholino and triphenylphosphonium moieties exhibiting a dominant lysosomal localisation profile, two dye conjugates showing intramolecular energy transfer, and two competitive antagonists, including vismodegib that binds to a G-protein coupled receptor in the Hedgehog signalling pathway and masupirdine, designed to target the serotonin GPCR.

