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Updated: Jan 15, 2026

Live Imaging to Study Microtubule Dynamic Instability in Taxane-resistant Breast Cancers
Published on: February 20, 2017
FROM INFUSION REACTION TO IMMUNE CASCADE: A CASE OF SEQUENTIAL TAXANE AND CAPECITABINE TOXICITIES IN TRIPLE-NEGATIVE
S Kordzaia1, E Dolmazashvili2, K Tsiklauri2
11Ltd "Multiprofile Clinic Consilium Medulla", Tbilisi; 2Ivane Javakhishvili Tbilisi State University, Georgia.
None:
This case report describes a 61-year-old female with stage IIIc triple-negative breast cancer (TNBC) who experienced a sequence of distinct treatment-related toxicities: a hypersensitivity reaction to paclitaxel, taxane-induced pneumonitis during subsequent docetaxel therapy, and radiation recall dermatitis (RRD) triggered by capecitabine administered after the completion of radiotherapy. The pneumonitis was successfully managed with corticosteroids, and the RRD resolved with topical therapy and dose modification. This case highlights the complex interplay of immune-mediated toxicities and underscores the importance of vigilant monitoring, individualized treatment adjustments, and multidisciplinary care in patients receiving sequential taxane-based chemotherapy, radiotherapy, and fluoropyrimidines.
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