Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

961
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
961
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.7K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraoperative pain sensitivity and aqueous humor inflammatory cytokine profiles in hepatitis C virus antibody-positive cataract patients.

International ophthalmology·2026
Same author

Comparisons of Intraocular Lens Calculation Formulas for Eyes With Astigmatism: Systemic Review and Network Meta-Analysis.

Journal of ophthalmology·2026
Same author

Accuracy of twelve intraocular lens calculation formulas in highly myopic eyes.

International ophthalmology·2026
Same author

Accuracy of Intraocular Lens Power Calculation Formulas in Cataract Eyes after Vitrectomy with Silicone Oil Tamponade: A Network Meta-Analysis.

Ophthalmic research·2026
Same author

The influence of keratometry on the accuracy of intraocular lens formulas in highly myopic eyes.

BMC ophthalmology·2026
Same author

Agreement between IOL Master 700 and Pentacam in measuring total keratometry and posterior keratometry across different axial lengths in cataract patients.

International ophthalmology·2025
Same journal

Discontinuing Anti-VEGF Therapy in Patients with Neovascular Age-Related Macular Degeneration That Remains Inactive with Treatment at the Maximum Injection Interval.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Ophthalmic Implications of Ehlers-Danlos Syndrome.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Diagnostic Value of Pupil Involvement and Yield of Vascular Imaging in Isolated Third Cranial Nerve Palsy: A 10-Year Retrospective Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Short-Term Preliminary Results of Outcomes with and without Tenonectomy During Open Conjunctival XEN45 Gel Stent Implantation.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Chemical and Thermal Ocular Burns in Children: A Retrospective Single-Center Study of Etiology, Clinical Characteristics, and Outcomes.

Clinical ophthalmology (Auckland, N.Z.)·2026
Same journal

Two-Year Follow-Up of the MINI WELL Non-Diffractive Extended Depth-of-Focus Intraocular Lens: A Retrospective Observational Study.

Clinical ophthalmology (Auckland, N.Z.)·2026
See all related articles

Related Experiment Video

Updated: Jan 15, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
05:19

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery

Published on: December 1, 2023

1.6K

Cataract Induced by Glucocorticoids.

Yu-Feng Jian1, Jing-Shang Zhang1, Xiu-Hua Wan1

  • 1Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing Key Laboratory of Ophthalmology and Vision Science, Beijing, 100730, People's Republic of China.

Clinical Ophthalmology (Auckland, N.Z.)
|October 13, 2025
PubMed
Summary
This summary is machine-generated.

Glucocorticoid-induced cataracts (GIC) are a major complication of long-term steroid use for autoimmune diseases. Understanding GIC

Keywords:
glucocorticoidglucocorticoid induced cataractintervention

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.8K
Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

10.3K

Related Experiment Videos

Last Updated: Jan 15, 2026

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery
05:19

Author Spotlight: Unraveling the Molecular Mechanisms in PCO and Fibrosis Following Cataract Surgery

Published on: December 1, 2023

1.6K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.8K
Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
13:56

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Published on: November 28, 2012

10.3K

Area of Science:

  • Ophthalmology and Pharmacology
  • Molecular Biology and Genetics
  • Epidemiology and Public Health

Background:

  • Glucocorticoids (GCs) are essential for treating noninfectious uveitis and autoimmune conditions.
  • Chronic GC administration frequently leads to sight-threatening complications, notably glucocorticoid-induced cataracts (GIC).
  • GIC significantly impairs visual acuity, photophobia, and overall quality of life.

Purpose of the Study:

  • To provide a comprehensive review of the molecular pathogenesis, epidemiology, and clinical management of GIC.
  • To synthesize current evidence to resolve the GC therapeutic paradox.
  • To establish robust frameworks for future clinical management of GIC.

Main Methods:

  • Systematic review and synthesis of current scientific evidence.
  • Epidemiological analysis of ocular complications in patients receiving systemic corticosteroids.
  • Review of histopathological findings and molecular mechanisms of GIC.
  • Analysis of risk stratification models for cataractogenesis.

Main Results:

  • Over 50% of patients on systemic corticosteroids for >60 days experience ocular complications, with cataracts (36%) and glaucoma (16%) being most common.
  • GIC involves posterior subcapsular opacities linked to oxidative stress, EMT, vimentin dysregulation, Na+/K+-ATPase inhibition, apoptosis, and ER stress.
  • Key risk factors for GIC include cumulative GC dose, treatment duration, and route of administration (oral > topical > intravitreal).

Conclusions:

  • GIC is a prevalent and debilitating complication of essential GC therapy.
  • Understanding the molecular pathogenesis and epidemiological patterns is crucial for effective management.
  • Future interventions should focus on antioxidants, targeted therapies, advanced drug delivery, and GC-sparing agents.