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TREATMENT OF LATERAL EPICONDYLITIS OF THE ELBOW WITH HYALURONIC ACID INJECTIONS
Mauro Emilio Conforto Gracitelli1, Luiza DE Campos Moreira DA Silva1, Jorge Henrique Assunção1,2
1. Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas (HCFMUSP), Sao Paulo, SP, Brazil.
Acta Ortopedica Brasileira
|October 15, 2025
Summary
Hyaluronic acid injections effectively treat lateral epicondylitis, significantly reducing pain and improving function. This study shows positive outcomes for tennis elbow patients with no reported complications.
Area of Science:
- Orthopedics
- Regenerative Medicine
Background:
- Lateral epicondylitis, commonly known as tennis elbow, is a degenerative condition affecting the forearm extensor tendons.
- Conservative treatments often fail, necessitating evaluation of alternative therapies like hyaluronic acid injections.
Purpose of the Study:
- To assess the efficacy of hyaluronic acid injections in treating lateral epicondylitis.
- To evaluate pain reduction and functional improvements following hyaluronic acid treatment.
Main Methods:
- A prospective cohort study involving 46 patients (52 elbows) with lateral epicondylitis.
- Patients received two hyaluronic acid injections one week apart.
- Pain (Visual Analogue Scale) and function (Single Assessment Numeric Evaluation) were assessed at multiple time points up to 12 months.
Main Results:
- Significant reduction in pain scores at rest and during maximum hand grip strength (p<0.001).
- Substantial improvement in functional assessment scores (SANE).
- No injection site complications were reported.
Conclusions:
- Hyaluronic acid injections provide a safe and effective treatment option for lateral epicondylitis.
- The treatment leads to statistically significant improvements in pain and function.
- This approach offers a promising alternative for patients with persistent tennis elbow symptoms.
