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Cambridge kidney One-Stop Mass Investigation Clinic (CkOSMIC): A Nonrandomised Feasibility Study
Chiara Re1, James P Blackmur2, Teele Kuusk2
1Department of Surgery, University of Cambridge, Cambridge, UK; Department of Urology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge, UK.
European Urology Oncology
|October 15, 2025
Summary
A new one-stop renal mass biopsy (RMB) clinic using confocal microscopy provides rapid, same-day results. This innovative approach improves diagnostic accuracy and significantly reduces patient wait times for treatment decisions.
Area of Science:
- Urology
- Nephrology
- Oncology
- Medical Diagnostics
Background:
- Renal mass biopsy (RMB) is crucial for diagnosing kidney masses.
- Traditional RMB pathways involve lengthy waiting times for results.
- Delays in diagnosis can increase patient anxiety and postpone treatment.
Purpose of the Study:
- To evaluate the feasibility and outcomes of a one-stop renal mass biopsy clinic.
- To assess the utility of confocal microscopy for same-day RMB results.
- To compare the efficiency and patient experience of the new clinic versus standard pathways.
Main Methods:
- Establishment of the Cambridge kidney One-Stop Mass Investigation Clinic (CkOSMIC).
- Ultrasound-guided RMB with immediate assessment via confocal laser microscopy.
- Comparison with a historical cohort undergoing standard pathology RMB.
- Assessment of feasibility, safety, diagnostic accuracy, and patient/clinician acceptability.
Main Results:
- The CkOSMIC clinic successfully performed 50 biopsies, with 48 patients receiving immediate provisional diagnoses.
- High diagnostic accuracy for malignancy: 94% sensitivity and 100% specificity.
- Significant reduction in time from consultation to treatment decision (25 vs. 55 days) and biopsy to treatment decision (0 vs. 24 days).
- High patient and clinician satisfaction reported.
Conclusions:
- The CkOSMIC one-stop clinic is a feasible and safe model for RMB.
- Confocal microscopy enables rapid, accurate diagnosis, improving efficiency.
- This pathway reduces hospital visits, shortens treatment decision timelines, and alleviates patient anxiety.
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