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Updated: Jan 15, 2026
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Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
Published on: August 16, 2021
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Beyond the Pump: Reframing Cardiogenic Shock in Heart Failure Through a Multisystem Mechanistic Lens
Ameesh Isath1, Akshay S Desai1, Mandeep R Mehra1
1Center for Advanced Heart Disease, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
JACC. Heart Failure
|October 16, 2025
Summary
Cardiogenic shock (CS) in acute-on-chronic heart failure (ACHF) requires new treatments beyond hemodynamics. Understanding ACHF-CS as a distinct shock type is key to improving patient outcomes.
Area of Science:
- Cardiology
- Critical Care Medicine
- Translational Research
Background:
- Current cardiogenic shock (CS) management, primarily hemodynamic optimization, yields poor outcomes for acute-on-chronic heart failure CS (ACHF-CS).
- The STEMI-CS model inadequately represents the complex physiology of ACHF-CS, which involves multisystem dysfunction.
- ACHF-CS is characterized by hemodynamic abnormalities, systemic inflammation, and microcirculatory dysfunction, leading to organ injury despite hemodynamic recovery.
Keywords:
cardiogenic shockheart failurehemodynamic dissonanceinflammationmetabolic dysfunctionmicrocirculationMore Related Videos
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