Related Experiment Video
Updated: Jan 14, 2026
Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
Platelet-Based Injections for Knee Osteoarthritis: Do They Work, Are They Safe?
Giulia M M Chiari Gaggia1, Pietro Conte1, Giuseppe Anzillotti1
1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan 20072, Italy; IRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano 20089, Italy.
Biological therapies like platelet-rich plasma (PRP), platelet-poor plasma (PPP), and autologous conditioned serum (ACS) show potential for knee osteoarthritis (KOA) treatment. Further research and standardized protocols are needed to optimize their use as alternatives to conventional therapies.
Area of Science:
- Orthopedics
- Regenerative Medicine
- Biotechnology
Background:
- Knee osteoarthritis (KOA) is a degenerative joint disease impacting millions globally.
- Current treatments for KOA have limitations in efficacy and safety.
- Biological therapies offer potential for cartilage repair and symptom management.
Purpose of the Study:
- To review the efficacy and safety of platelet-rich plasma (PRP), platelet-poor plasma (PPP), and autologous conditioned serum (ACS) for knee osteoarthritis (KOA).
- To assess the current evidence supporting these biological therapies in KOA management.
Main Methods:
- Systematic review of existing literature on PRP, PPP, and ACS for KOA.
- Analysis of study outcomes focusing on pain reduction, functional improvement, and safety profiles.
- Evaluation of the impact of preparation methods and product composition.
Main Results:
- Platelet-rich plasma (PRP) demonstrates variable efficacy, influenced by preparation techniques.
- Platelet-poor plasma (PPP) is associated with a reduced risk of inflammatory reactions.
- Autologous conditioned serum (ACS) shows promise in reducing KOA symptoms due to its anti-inflammatory properties.
Conclusions:
- PRP, PPP, and ACS represent promising alternative treatments for knee osteoarthritis.
- Standardized protocols for preparation and administration are crucial for consistent outcomes.
- Further high-quality research is necessary to establish optimal clinical guidelines and long-term efficacy.
