Optical correction in excised cataractous crystalline lenses by using wavefront shaping techniques

Cataracts significantly degrade retinal image quality by scattering light within the crystalline lens. In this work, we apply wavefront shaping techniques to optimize the point spread function (PSF) formed through excised human lenses at advanced cataract stages, enabling improved image formation on the retinal plane. We employed both phase and binary amplitude modulation strategies with matched degrees of freedom for fair comparison. We analyze the isoplanatic patch size and demonstrate that concatenating multiple optimized PSFs can extend the effective imaging area. These results show the potential of wavefront shaping as a non-invasive, purely optical strategy for correcting cataract-induced image blur in the eye.