Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ion Exchange01:17

Ion Exchange

1.1K
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
1.1K
Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

1.6K
Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at...
1.6K
Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

1.8K
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
1.8K
Affinity Chromatography01:03

Affinity Chromatography

2.8K
Affinity chromatography is a powerful technique extensively utilized for separating and purifying specific biomolecules from complex mixtures. It capitalizes on the highly selective binding between an analyte and its counterpart, such as antibody-antigen interactions. The counterpart is immobilized on the stationary phase, forming an affinity column. The stationary phase typically consists of solid support, such as agarose or porous glass beads, immobilizing the affinity ligand. The mobile...
2.8K
Detergent Purification of Membrane Proteins01:18

Detergent Purification of Membrane Proteins

6.3K
Detergents are used to purify the integral proteins of the membrane. The hydrophobic portion of the detergent can replace membrane phospholipids while solubilizing the membrane proteins. When detergent monomers reach a specific concentration in a solution called critical micelle concentration (CMC), they form micelles. Above CMC, the concentration of the detergent monomers remains in equilibrium with the micelle. The number of detergent monomers present in the CMC varies for each detergent, and...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tuning Ion Dynamics and Structure via Polyzwitterionic Chemistry and Architecture in Polymer-Supported Ionic Liquid Electrolytes.

The journal of physical chemistry. B·2026
Same author

Influence of Rigidity-Hydration Coupling on Size-Dependent Diffusion in Hydrated Polymer Membranes.

ACS macro letters·2026
Same author

Interfacial Cation Arrangement Controls Electrocatalytic Kinetics in CO<sub>2</sub> Reduction.

Journal of the American Chemical Society·2025
Same author

Field-Driven Simulations to Probe the Impact of Ionic Correlations on Solution Transport Coefficients in Binary, Ternary, and Reciprocal Quaternary Aqueous Electrolytes.

Journal of chemical theory and computation·2025
Same author

Anomalous Ion Transport in 2D Graphene Oxide Nanochannels Enabled by Hydration Mimicry with Confined Amino Acids.

Nano letters·2025
Same author

Impact of Ligands on the Ion-Ion Selectivity of Ligand-Appended-Pillar[<i>n</i>]arene Channels.

The journal of physical chemistry. B·2025

Related Experiment Video

Updated: Jan 14, 2026

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes
07:45

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes

Published on: August 16, 2018

10.4K

Ligand-Functionalized Polymer Membranes for Selective Ion Separations.

Venkat Ganesan1, Everett Zofchak1

  • 1McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, Texas 78712, United States.

ACS Macro Letters
|October 20, 2025
PubMed
Summary
This summary is machine-generated.

Ligand-functionalized membranes enable precise ion separations by embedding molecular recognition into polymer matrices. This approach overcomes limitations of conventional membranes, paving the way for advanced water purification and energy technologies.

More Related Videos

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
10:27

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

10.5K
Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
08:06

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Published on: February 23, 2017

8.9K

Related Experiment Videos

Last Updated: Jan 14, 2026

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes
07:45

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes

Published on: August 16, 2018

10.4K
Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
10:27

Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides

Published on: July 14, 2015

10.5K
Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
08:06

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone

Published on: February 23, 2017

8.9K

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Environmental Science

Background:

  • Selective ion separations are critical for water purification, resource recovery, and clean energy applications.
  • Conventional polymer membranes face challenges in discriminating between similar ions, especially in high-ionic-strength conditions.
  • Ligand-functionalized membranes offer a promising alternative by integrating molecular recognition for enhanced selectivity.

Purpose of the Study:

  • To highlight the structure-function relationships in ligand-mediated ion separation.
  • To discuss design principles for optimizing ligand-functionalized membranes.
  • To explore emerging strategies for next-generation ion separation technologies.

Main Methods:

  • Review and analysis of structure-function relationships in ligand-mediated ion separation.
  • Discussion of key design parameters including ligand coordination, dehydration penalties, and nanoscale confinement.
  • Examination of permeability-selectivity trade-offs, multicomponent effects, and membrane stability.

Main Results:

  • Ligand design (denticity, donor identity, rigidity, spatial organization) significantly impacts ion selectivity and transport.
  • The interplay between dehydration penalties, coordination chemistry, and confinement dictates separation efficiency.
  • Current limitations include stability challenges and performance in complex ionic environments.

Conclusions:

  • Ligand-functionalized membranes represent a transformative strategy for precise and energy-efficient ion separations.
  • Bioinspired ligands and computational design are emerging as powerful tools for developing advanced membranes.
  • Further research into design principles and stability is crucial for realizing the full potential of these technologies.