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Published on: May 18, 2019
Itch: From Bench to Bedside
Aaron M Ver Heul1, Brian S Kim2
1Division of Allergy & Immunology, John T. Milliken Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA; Immunology and Inflammation Therapeutic Area, Sanofi, 450 Water Street, Cambridge, MA 02141, USA.
Abstract:
Itch is one of the most commonly encountered symptoms in allergy clinics. Until recently, effective therapies for itch were limited, but now there are multiple classes of drugs that can target distinct forms of itch. Despite this remarkable progress, variability in therapeutic outcomes underscores unmet needs in treating pruritic skin diseases. As a paradigm of neuroimmune crosstalk, insight into basic mechanisms of itch may shed new light on conditions beyond the skin. This article discusses basic preclinical scientific studies of itch neuroimmunology and how approved medications for pruritic skin diseases are informing development of the next generation of treatments.
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