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Non-IgE-Mediated Hypersensitivity to Amoxicillin Following Epstein-Barr Virus Infection: A Case Report
Lara Margarida Navarro1, Ana Isabel Moreira Ribeiro1, Cláudia Patraquim1
1Department of Pediatrics, Unidade Local de Saúde de Braga, Braga, PRT.
Cureus
|October 28, 2025
Summary
Epstein-Barr virus (EBV) infection can cause amoxicillin rashes mimicking viral exanthems. Allergy testing revealed a non-immediate hypersensitivity reaction to amoxicillin, highlighting EBV
Area of Science:
- Pediatric Allergy and Immunology
- Infectious Diseases
- Clinical Pharmacology
Background:
- Rashes in children with Epstein-Barr virus (EBV) infection treated with amoxicillin can be mistaken for viral exanthems.
- Differentiating viral exanthems from drug hypersensitivity is crucial for appropriate patient management.
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