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Related Experiment Video

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Early Motor Cortex Connectivity and Neuronal Reactivity in Intracerebral Hemorrhage: A Continuous-Wave Functional

Nitin Kumar1, Geetha Charan Duba2, Nabeela Khan3

  • 1Department of Biological Sciences, Faculty of Science, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Sensors (Basel, Switzerland)
|October 29, 2025
PubMed
Summary

Motor cortex reorganization in acute stroke patients was investigated using functional near-infrared spectroscopy. Findings suggest the premotor cortex plays a role in motor cortex remodeling following intracerebral hemorrhage.

Keywords:
acute strokefunctional near-infrared spectroscopy (fNIRS)intracerebral hemorrhage (ICH)resting-state functional connectivity (RSFC)

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Medical Imaging

Background:

  • Understanding motor cortex remodeling is crucial for developing effective acute rehabilitation strategies after stroke.
  • Intracerebral hemorrhage (ICH) can lead to significant alterations in brain function and connectivity.

Purpose of the Study:

  • To assess resting-state functional connectivity (RSFC) and reactivity in the motor, premotor, and somatosensory cortex in patients with acute ICH.
  • To compare these measures between affected and unaffected hemispheres and with matched control subjects using continuous wave functional near-infrared spectroscopy (cw-fNIRS).

Main Methods:

  • Recruited patients with acute-subacute hemispheric ICH (n=37) and matched controls (n=44).
  • Assessed RSFC using seed-based correlation analysis focusing on the primary motor cortex (priMC).
  • Analyzed functional task (FT)-associated relative oxyhemoglobin (ΔHbO) changes using generalized linear model regression.

Main Results:

  • In left hemispheric ICH, increased resting-state coherence was observed between the affected priMC and premotor cortex (preMC).
  • In right hemispheric ICH, decreased coherence was found between the unaffected priMC and the affected preMC.
  • Left-hand FT showed increased ΔHbO over the affected preMC in left ICH, and over the unaffected preMC in right ICH.

Conclusions:

  • The left premotor cortex (preMC) appears to be involved in motor cortex reorganization in acute ICH, regardless of stroke laterality.
  • These findings highlight potential targets for motor rehabilitation during the acute phase of stroke.
  • Further longitudinal studies are needed to track motor cortex reorganization and inform rehabilitation timing and strategies.