Machine Learning and Artificial Intelligence-Based Clinical Decision Support for Modern Hematology.
Cindy Zhang1, Barbara D Lam2, Fabienne Lucas1
1Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
Clinics in Laboratory Medicine
|October 29, 2025
Summary
Machine learning (ML) is transforming hematology diagnostics. This review explores ML applications, successes, and limitations across hematology subdomains for healthcare professionals.
Area of Science:
- Medical Informatics
- Clinical Pathology
- Computational Biology
Background:
- Hematology is a data-rich medical field.
- Technological innovation is rapidly advancing hematology.
- Machine learning (ML) integration into diagnostics is increasing.
Purpose of the Study:
- To review the current landscape of ML research and clinical applications in hematology.
- To inform healthcare professionals about ML's impact on workflows.
- To explore successes and limitations of ML in hematology.
Main Methods:
- Literature review of ML in hematology.
- Analysis of research across various hematology subdomains.
- Examination of clinical applications and deployments.
Main Results:
- ML shows significant potential in diverse hematology areas.
- Successes are noted in hematopathology, hemoglobinopathies, and coagulopathy.
- Limitations and challenges in ML research and deployment are identified.
Conclusions:
- Understanding ML is crucial for hematology care teams.
- ML tools require careful integration into clinical workflows.
- Further research is needed to address ML limitations in hematology.
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