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Updated: Jan 12, 2026

Controlled Photoredox Ring-Opening Polymerization of O-Carboxyanhydrides Mediated by Ni/Zn Complexes
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Solvent-Dependent Oxidative Ring Opening of Cyclopropylamides Mediated by Halogen Bonding

Chaoxiang Ning1, Jiye Shu1, Xiaojun Zeng2

  • 1Jiangxi Province Key Laboratory of Drug Target Discovery and Validation, School of Pharmacy, Nanchang University, Nanchang 330031, China.

The Journal of Organic Chemistry
|November 3, 2025
PubMed
Summary

A new solvent-dependent method enables the oxidative ring opening of cyclopropylamides using N-iodosuccinimide (NIS). This approach yields either 3-iodo N,O-acetals or 1,3-oxazines, offering a versatile synthetic strategy.

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Halogenation of Alkenes02:46

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Consider the bromination of cyclopentene. Molecular bromine is polarized in the proximity of the π electrons of cyclopentene. An electrophilic bromine atom adds across the double bond, forming a cyclic bromonium ion intermediate.
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