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Hyperkalemia-related mortality trends in cardiac arrest: a 1999-2020 analysis in the United States

Javeria Akhter1, Taha Abdul Ahad2, Sharmeen Riaz2

  • 1Lung Health Department, Indus Hospital and Health Network, Karachi, Pakistan.

Annals of Medicine and Surgery (2012)
|November 3, 2025
PubMed

Insights

Cardiac arrest deaths linked to hyperkalemia in US adults (15+) have risen since 2007. Targeted interventions are crucial to address increasing mortality rates, particularly in vulnerable populations.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Cardiac arrest remains a significant cause of mortality in the US.
  • Limited research exists on hyperkalemia-associated cardiac arrest mortality.
  • This study addresses trends and regional disparities in hyperkalemia-related cardiac arrest deaths.

Purpose of the Study:

  • To analyze temporal trends in cardiac arrest mortality due to hyperkalemia.
  • To investigate regional variations in hyperkalemia-related cardiac arrest deaths.
  • To examine demographic factors influencing hyperkalemia-associated mortality.

Main Methods:

  • Utilized the CDC WONDER database (1999-2020) for US mortality data.
  • Calculated age-adjusted mortality rates (AAMRs) per 100,000 individuals.
  • Stratified analysis by year, sex, age, urbanization, race, and geographic region.

Main Results:

  • Over 36,000 hyperkalemia-related cardiac arrest deaths occurred (1999-2020).
  • AAMR decreased until 2007, then increased significantly, reaching 9.5 in 2020.
  • Males, older adults (85+), and NH Black or African American individuals exhibited higher mortality rates.

Conclusions:

  • Mortality from hyperkalemia-associated cardiac arrest has been increasing since 2007.
  • Effective hyperkalemia management strategies are needed to curb rising death rates.
  • Interventions must consider specific demographic and geographic risk factors.
Abstract

Keywords:
CDC WONDERUSAcardiac arresthyperkalemiamortality

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